Search results for "Pulmonary and Respiratory Medicine"

New populations of the threatened fern Equisetum moorei Newman in the Valencian Community (Spain)

2020

Se aportan nuevas citas del helecho amenazado Equisetum moorei en la Comunidad Valenciana, donde solo se conocían previamente seis localidades con presencia actual de la especie. Una de las nuevas poblaciones am­plía notablemente el área de distribución conocida en esta región, ya que la mayor parte de las localidades conocidas se concentraban en el macizo del Peñagolosa (provincia de Castellón). Se describen las características ecológicas y demográficas de las nuevas localidades en el contexto de las poblaciones previamente conocidas en la región valenciana.

An international registry for primary ciliary dyskinesia

2016

Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder leading to chronic upper and lower airway disease. Fundamental data on epidemiology, clinical presentation, course and treatment strategies are lacking in PCD. We have established an international PCD registry to realise an unmet need for an international platform to systematically collect data on incidence, clinical presentation, treatment and disease course.The registry was launched in January 2014. We used internet technology to ensure easy online access using a web browser under www.pcdregistry.eu. Data from 201 patients have been collected so far. The database is comprised of a basic data form including demographic…

Clinical utility of plasma-based digital next-generation sequencing in oncogene-driven non-small-cell lung cancer patients with tyrosine kinase inhib…

2019

[Objectives] Resistance to tyrosine-kinase inhibitors (TKIs) is a clinical challenge in patients with oncogene-driven non-small-cell lung cancers (NSCLC). We have analyzed the utility of next-generation sequencing (NGS) of cell-free circulating tumor DNA (ctDNA) to impact the clinical care of patients with TKI resistance.

A phase I study of nintedanib combined with cisplatin/gemcitabine as first-line therapy for advanced squamous non-small cell lung cancer (LUME-Lung 3)

2018

Abstract Background There are limited treatment options for squamous non-small cell lung cancer (sqNSCLC) and prognosis remains poor. The safety and pharmacokinetics (PK) of nintedanib, a triple angiokinase inhibitor, plus cisplatin/gemcitabine as first-line treatment for advanced sqNSCLC patients, were evaluated. Materials and methods A phase I, dose-escalation study administering drugs in a 21-day cycle: cisplatin (75 mg/m2, Day 1), gemcitabine (1250 mg/m2, Days 1 and 8) and nintedanib (Days 2–7, 9–21) were given for 4–6 cycles, followed by monotherapy until disease progression or adverse events (AEs). Two nintedanib doses were tested, 150 mg twice daily (bid) and 200 mg bid, to determine…

Anti-cancer activity of dose-fractioned mPE +/- bevacizumab regimen is paralleled by immune-modulation in advanced squamous NSLC patients

2017

Background: Results from the BEVA2007 trial, suggest that the metronomic chemotherapy regimen with dose-fractioned cisplatin and oral etoposide (mPE) +/− bevacizumab, a monoclonal antibody to the vascular endothelial growth factor (VEGF), shows anti-angiogenic and immunological effects and is a safe and active treatment for metastatic non-small cell lung cancer (mNSCLC) patients. We carried out a retrospective analysis aimed to evaluate the antitumor effects of this treatment in a subset of patients with squamous histology. Methods: Retrospective analysis was carried out in a subset of 31 patients with squamous histology enrolled in the study between September 2007 and September 2015. All o…

Exosomes in lung cancer liquid biopsies: Two sides of the same coin?

2017

LETTER TO EDITOR

Infestación pulmonar por Strongyloides stercoralis

2016

Méthodes d’identification et de quantification des moisissures de l’habitat : méthodes classiques, méthodes moléculaires

2017

Resume Introduction Pour apprehender les repercussions de l’inhalation constante et inevitable de spores de moisissures il est necessaire de les prelever, les identifier et les quantifier. Etat des lieux Les prelevements sont de trois types : (i) surfaces, de realisation facile mais non quantifiables, (ii) air, faciles a calibrer mais limites dans le temps, et (iii) poussieres, plus representatifs dans le temps d’une exposition aux moisissures. La strategie d’echantillonnage depend des objectifs (exposition des personnes, objectiver la contamination, efficacite de la remediation). L’identification des colonies obtenues en culture est realisee par microscopie, Maldi-TOF, et/ou par sequencage…

Association between urticaria and nematode infections

2018

Background The association between parasites and urticaria was first suggested in the last century. A wide range, 0-75.4%, of the prevalence of parasitic infection has been reported with chronic urticaria (CU). Moreover, urticaria may be detected in patients with parasitosis. Nematodes are a type of helminth that infect hundreds of millions of people throughout the world. Objective The aim of this work was to collect and review the published studies and cases of urticaria associated with nematode infections. Methods A search of scientific literature data bases from January 1960 until May 2017 was carried out. Results Numerous nematode infections have been associated with urticaria and/or an…

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions

2016

A major cause of respiratory failure during influenza A virus (IAV) infection is damage to the epithelial–endothelial barrier of the pulmonary alveolus. Damage to this barrier results in flooding of the alveolar lumen with proteinaceous oedema fluid, erythrocytes and inflammatory cells. To date, the exact roles of pulmonary epithelial and endothelial cells in this process remain unclear.Here, we used an in vitro co-culture model to understand how IAV damages the pulmonary epithelial–endothelial barrier. Human epithelial cells were seeded on the upper half of a transwell membrane while human endothelial cells were seeded on the lower half. These cells were then grown in co-culture and IAV wa…